If interested, please send your CV to marziyeh.karimiavargani@umontreal.ca
Job Description Summary
Do you enjoy solving complex problems, building relationships with collaborators, and continuously learning in a fast-paced and innovative environment? Michnick lab is looking for a highly motivated, early-career scientist interested in an alternative to the traditional academic career path. Join our team of Scientists Helping Scientists and build a stable and rewarding scientific career.
As a Scientist in our quantitative cell and molecular biology group, your creative mindset, combined with your deep technical knowledge of genome engineering will be utilized for development of novel multivalent therapeutic recombinant antibodies and screens for potential targets of chemical inducers of protein proximity for treatment of a variety of diseases and for regenerative medicine. You will also perform fundamental mechanistic studies to multivalent antibody and chemically-induced proximity of proteins effects on cellular pathways that result in a desired response.
Duties and responsibilities
- Design, execute, and optimize research with the aims of practical testing of multivalent antibodies and screens for chemically-induced proximity protein candidates and mechanistic studies of cellular responses.
- Analyze and present experimental data to a wide range of audiences.
- Dissect published literature to find novel solutions to gene editing challenges.
- Generate, manage, evaluate, and maintain critical data in a highly organized manner, providing statistical analysis and troubleshooting where appropriate.
- Independently design and execute experiments, analyze data, perform literature reviews, and prepare scientific documents.
Knowledge and qualifications
- Expertise in the design and construction of nucleic acids for expression in human cells, using modern molecular biology techniques including Gibson cloning, golden gate cloning, PCR, gel electrophoresis, bacterial transformation, and sequencing.
- Expertise in mammalian cell culture, high-throughput cellular assays, and diverse nucleic acid delivery methods (e.g. lipofection, nucleofection, lipid nanoparticles, viral vectors).
- Expertise in standard cell and molecular biology assays, including next generation sequencing, qPCR/ddPCR, flow cytometry, microscopy, and protein assays.
- Expertise in CRISPR and gene editing concepts.
- Expertise in experimental design and data analysis, especially with regard to gene editing outcomes.
- Ph.D. in biology, bioengineering, or related discipline.
- 0-3 years of relevant experience focused on gene editing technologies.
- Academic and/or industry experience in the field with track record demonstrating significant contributions.
- Outstanding problem-solving skills and attitude to think outside the box.
- Excellent writing, reviewing, and presentation skills.
- Track record of intellectually challenging oneself to enhance scientific capabilities.
- Ability to work independently as well as collaboratively in a results-oriented research team environment.
- Must possess critical thinking and self-reliance to solve tasks independently.
- Proven ability to work in cross-functional teams, communicate with key opinion leaders and collaborators, and provide supervision to junior colleagues.
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